研究领域

1、基于手性技术的碳碳键及碳杂原子键的形成方法学，以及新型手性催化剂的设计合成及应用研究。 

2、基于新概念，新试剂和新反应的新型杂环化合物的设计合成及其生理活性研究。 

3、化学创新药物及"Me Too"药物的绿色合成技术的开发研究。 

4、基于组蛋白去乙酰化酶（HDAC）抑制剂的靶向小分子抗肿瘤药物研究。

论文与著作

1. Zhang Jian, Ni Tao, Yang Wu-Lin, Deng Wei-Ping. Catalytic Asymmetric [3 + 2] Annulation via Indolyl Copper-Allenyliende Intermediates: Diastereo- and Enantioselective Assembly of Pyrrolo[1,2-a]indoles. Org. Lett., 2020, DOI: org/10.1021/acs.orglett.0c01594.

2. Yang Wu-Lin, Li Wen, Yang Zhong-Tao, Deng Wei-Ping. Organocatalytic Regiodivergent Ring Expansion of Cyclobutanones for the Enantioselective Synthesis of Azepino[1,2‑a]indoles and Cyclohepta[b]indoles. Org. Lett. 2020, 22, 4026-4032.

3. Zou Xue-Jie, Yang Wu-Lin, Zhu Jing-Yan, Deng Wei-Ping. Catalytic Enantioselective Formal Synthesis of MDM2 Antagonist RG7388 and Its Analogue. Chin. J. Chem., 2020, 38(5), 435-438.

4. Zheng Xing, Sun Hao, Yang Wu-Lin, Deng Wei-Ping. Elaboration of phosphoramidite ligands enabling palladium-catalyzed diastereo- and enantioselective all carbon [4+3] cycloaddition. Sci. Chin. Chem., 2020, DOI:  10.1007/s11426-020-9718-2.

5. Zou Xuejie, Liu Yangzi, Shang Shaojing, Yang Wulin, Deng Wei-Ping. Diastereoselective Synthesis of Functionalized Tetrahydro-γ-Carbolines via a [3+3] Cycloaddition of 2,2'-Diester Aziridines with β-(Indol-2-yl)-α,β-unsaturated Ketones. Chin. Chem. Lett., 2020, 31, 1293-1296.

6. Yang Wulin, Wang Hao, Pan Zirong, Li Zhong, Deng Weiping. Asymmetric synthesis of pyrrolo[1,2-a]indoles via organocatalytic[3+2] annulation of substituted 2-vinylindoles with azlactones. Chin. Chem. Lett., 2020, 31, 721-724.

7. Liu Yang-Zi, Wang Zhongao, Huang Zesheng, Zheng Xing, Yang Wu-Lin, Deng Wei-Ping. Palladium-Catalyzed Asymmetric [4 + 3] Cyclization of Trimethylenemethane: Regio-, Diastereo-, and Enantioselective Construction of Benzofuro[3,2-b]azepine Skeletons. Angew. Chem. Int. Ed., 2020, 59, 1238-1242.

8. Leng Jiaying, Xu Hui, Meng Jiang, Luo Xiaoyan, Deng Wei-Ping. Transition-metal-free synthesis of polysubstituted pyrrole derivatives via [4+1] annulation of beta-keto acids (C1 synthon) and alpha,beta-unsaturated imines. Tetrahedron, 2019, 75, 130709.

9. Zhu Jinbin, Huang Linwei, Dong Wei, Li Naikai, Yu Xingxin, Deng Wei-Ping, Tang Wenjun. Enantioselective Rhodium-Catalyzed Addition of Arylboroxines to N-Unprotected Ketimines: Efficient Synthesis of Cipargamin. Angew. Chem. Int. Ed., 2019, 58, 16119-16123. (VIP)

10. Chen Long, Yang Wu-Lin, Shen Jia-Huan, Deng Wei-Ping. Nickel(II)-Catalyzed Diastereo- and Enantioselective Michael/Hemiacetalization Cascade Reaction of α-Ketoesters with 2-(2-Nitrovinyl)phenols. Adv. Synth. Catal., 2019, 361(19), 4611-4622.

11. Mao Jia, Zhang Hao, Ding Xiang-Feng, Luo Xiaoyan, Deng Wei-Ping. Synergistic Catalysis for Asymmetric [3 + 2] Cycloadditions of 2-Indolylmethanols with α,β-Unsaturated Aldehydes. J. Org. Chem. 2019, 84(17), 11186-11194.

12. Wu Shu-Xiao, Gu Bo-Qi, Xu Hui, Zheng Xing, Luo Xiaoyan, Deng Wei-Ping. Organocatalytic Asymmetric Inverse-Electron-Demand Diels-Alder Reaction of Pyrrolidone-Dienes with Enals. Adv. Synth. Catal., 2019, 361(18), 4302-4313.

13. Deng Hua, Jia Renmeng, Yang Wu-Lin, Yu Xingxin, Deng Wei-Ping. Ligand-Controlled Switch in Diastereoselectivities: Catalytic Asymmetric Construction of Spirocyclic Pyrrolidine-azetidine/oxe(thie)tane Derivatives. Chem. Commun., 2019, 55, 7346-7349.

14. Ding Xiang-Feng, Yang Wu-Lin, Mao Jia, Cao Cong-Xian, Deng Wei-Ping. Enantioselective Construction of Dihydropyrido[1,2-a]indoles via Organocatalytic Arylmethylation of 2-Enals with Inert Aryl Methane Nucleophiles. Org. Lett., 2019, 21, 5514-5518.

15. Jin Jing-Hai, Zhao Jianhong, Yang Wu-Lin, Deng Wei-Ping. Asymmetric synthesis of spirooxindole β-lactams via isothiourea-catalyzed Mannich/lactamization reaction of aryl acetic acids with isatin-derived ketimines. Adv. Synth. Catal., 2019, 361(7), 1592-1596.

16. Yang Zhong-Tao, Zhao Jianhong, Yang Wu-Lin, Deng Wei-Ping. Enantioselective Construction of CF₃‑Containing Spirooxindole γ‑Lactones via Organocatalytic Asymmetric Michael/Lactonization. Org. Lett., 2019, 21, 1015-1020.

17. Yang Wu-Lin, Sun Zhong-Tao, Sun Hao, Deng Wei-Ping. Nickel(II)-Catalyzed Diastereo- and Enantioselective [3+2] Cycloaddition of α-Ketoesters with 2-Nitrovinylindoles and 2-Nitrovinylpyrroles. Chin. J. Chem., 2019, 37, 216-220.

18. Yang Wu-Lin, Sun Zhong-Tao, Zhang Jian, Li Zhong, Deng Wei-Ping. Enantioselective synthesis of 3-amino-hydrobenzofuran-2,5-diones via Cu(I)-catalyzed intramolecular conjugate addition of imino esters. Org. Chem. Front., 2019, 6, 579-583.

荣誉与奖励

《药物化学（I）》上海市重点课程负责人，参编尤启东主编的《药物化学》国家规划教材。曾获上海市浦江人才、教育部新世纪优秀人才、上海市曙光学者等省部级人才称号；获上海市教学成果奖一等奖两项。兼任上海市药学会药物化学专委会委员，中国医药工业杂志编委等职。译著《药物考》和《创新药物发现---实践、过程和展望》等。